Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures

Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures

Atypical febrile seizures are considered a risk factor for epilepsy onset and cognitive impairments later in life. Patients with temporal lobe epilepsy and a history of atypical febrile seizures often carry a cortical malformation. This association has led to the hypothesis that the presence of a co...

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Bibliographic Details
Main Authors: Patricia N. Awad, Nathalie T. Sanon, Bidisha Chattopadhyaya, Josianne Nunes Carriço, Mohamed Ouardouz, Jonathan Gagné, Sandra Duss, Daniele Wolf, Sébastien Desgent, Laura Cancedda, Lionel Carmant, Graziella Di Cristo
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Neurobiology of Disease
Subjects:
Atypical febrile seizures
Temporal lobe epilepsy
Cortical dysplasia
KCC2
Seizure susceptibility
Dendritic spines
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300353

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http://www.sciencedirect.com/science/article/pii/S0969996116300353

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