Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?

Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?

Abstract Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of cancers. PD-L1 is constitutively expressed in certain tumors and host immune cells, and its expression can be induced or maintained by many factors. The expression of P...

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Bibliographic Details
Main Authors: Fei Tang, Pan Zheng
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Cell & Bioscience
Subjects:
PD-L1
PD-1/PD-L1 blockade
Cancer immunotherapy
Host immune cells
Immune evasion
Immune therapeutic effect
Online Access:http://link.springer.com/article/10.1186/s13578-018-0232-4

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http://link.springer.com/article/10.1186/s13578-018-0232-4

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