ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response.

Bibliographic Details
Main Authors: Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen, Zhenkun Lou
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05161-0

Internet

https://doi.org/10.1038/s41467-018-05161-0

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