Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

Summary: Previous studies have suggested that the loss of the translation initiation factor eIF4G1 homolog NAT1 induces excessive self-renewability of naive pluripotent stem cells (PSCs); yet the role of NAT1 in the self-renewal and differentiation of primed PSCs is still unclear. Here, we generate...

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Bibliographic Details
Main Authors: Kazutoshi Takahashi, Daeun Jeong, Songnan Wang, Megumi Narita, Xuemei Jin, Mio Iwasaki, Samuel D. Perli, Bruce R. Conklin, Shinya Yamanaka
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
endogenous retrovirus
translation
pluripotency
neural differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306926

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http://www.sciencedirect.com/science/article/pii/S2211124720306926

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