Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

NODAL/Activin signaling orchestrates key processes during embryonic development via SMAD2. How SMAD2 activates programs of gene expression that are modulated over time however, is not known. Here we delineate the sequence of events that occur from SMAD2 binding to transcriptional activation, and the...

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Bibliographic Details
Main Authors: Davide M Coda, Tessa Gaarenstroom, Philip East, Harshil Patel, Daniel S J Miller, Anna Lobley, Nik Matthews, Aengus Stewart, Caroline S Hill
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
SMAD2
chromatin remodeling
NODAL/Activin
transcription
signaling dynamics
Online Access:https://elifesciences.org/articles/22474

Internet

https://elifesciences.org/articles/22474

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