Precise determination of input-output mapping for multimodal gene circuits using data from transient transfection.

The mapping of molecular inputs to their molecular outputs (input/output, I/O mapping) is an important characteristic of gene circuits, both natural and synthetic. Experimental determination of such mappings for synthetic circuits is best performed using stably integrated genetic constructs. In mamm...

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Bibliographic Details
Main Authors: Christoph Stelzer, Yaakov Benenson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008389