The Ubiquitin-Conjugating Enzyme E2-EPF Is Overexpressed in Primary Breast Cancer and Modulates Sensitivity to Topoisomerase II Inhibition

The Ubiquitin-Conjugating Enzyme E2-EPF Is Overexpressed in Primary Breast Cancer and Modulates Sensitivity to Topoisomerase II Inhibition

We identified the ubiquitin-conjugating enzyme E2EPF mRNA as differentially expressed in breast tumors relative to normal tissues and performed studies to elucidate its putative role in cancer. We demonstrated that overexpression of E2-EPF protein correlated with estrogen receptor (ER) negativity i...

Full description

Bibliographic Details
Main Authors: Donato Tedesco, Jianhuan Zhang, Lan Trinht, Guita Lalehzadeh, Rene Meisner, Ken D. Yamaguchi, Daniel L. Ruderman, Harald Dinter, Deborah A. Zajchowski
Format: Article
Language:English
Published: Elsevier 2007-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
E2-EPF
etoposide
doxorubicin
topoisomerase II
breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800856

Internet

http://www.sciencedirect.com/science/article/pii/S1476558607800856

Similar Items