The Ubiquitin-Conjugating Enzyme E2-EPF Is Overexpressed in Primary Breast Cancer and Modulates Sensitivity to Topoisomerase II Inhibition
We identified the ubiquitin-conjugating enzyme E2EPF mRNA as differentially expressed in breast tumors relative to normal tissues and performed studies to elucidate its putative role in cancer. We demonstrated that overexpression of E2-EPF protein correlated with estrogen receptor (ER) negativity i...
Main Authors: | Donato Tedesco, Jianhuan Zhang, Lan Trinht, Guita Lalehzadeh, Rene Meisner, Ken D. Yamaguchi, Daniel L. Ruderman, Harald Dinter, Deborah A. Zajchowski |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2007-07-01
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Series: | Neoplasia: An International Journal for Oncology Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558607800856 |
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