Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP.

Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP.

C/EBP-homologous protein (CHOP) is a key determinant of the apoptotic response to endoplasmic reticulum stress or DNA damage. As a member of the C/EBP family, CHOP contains a low complexity N-terminal region involved in transcriptional activation, followed by a bZIP that binds DNA after dimerization...

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Bibliographic Details
Main Authors: Ángeles Canales, Marcel Rösinger, Javier Sastre, Isabella C Felli, Jesús Jiménez-Barbero, Guillermo Giménez-Gallego, Carlos Fernández-Tornero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5718554?pdf=render

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http://europepmc.org/articles/PMC5718554?pdf=render

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