Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

Abstract The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of mycobacterial diacyltrehalose (DAT) th...

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Bibliographic Details
Main Authors: Josephine F. Reijneveld, Mira Holzheimer, David C. Young, Kattya Lopez, Sara Suliman, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, Eri Ishikawa, Sho Yamasaki, Adriaan J. Minnaard, D. Branch Moody, Ildiko Van Rhijn
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81474-3

Internet

https://doi.org/10.1038/s41598-021-81474-3

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