Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

The emergence of bacterial resistance to traditional small-molecule antibiotics is fueling the search for innovative strategies to treat infections. Inhibiting the expression of essential bacterial genes using antisense oligonucleotides (ASOs), particularly composed of nucleic acid mimics (NAMs), ha...

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Bibliographic Details
Main Authors: Sara Souto Pereira, Ruwei Yao, Mariana Gomes, Per Trolle Jørgensen, Jesper Wengel, Nuno Filipe Azevedo, Rita Sobral Santos
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antibiotics
Subjects:
antibacterial drug
vitamin B<sub>12</sub>
antisense oligonucleotides
nucleic acid mimics
LNA
2′OMe
Online Access:https://www.mdpi.com/2079-6382/10/4/379

Internet

https://www.mdpi.com/2079-6382/10/4/379

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