Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

Abstract Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24‐hydroxylase (CYP46A1), a brain‐specific enzyme responsible for the elimination of cholesterol throu...

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Bibliographic Details
Main Authors: Mingzhi Han, Shuai Wang, Ning Yang, Xu Wang, Wenbo Zhao, Halala Sdik Saed, Thomas Daubon, Bin Huang, Anjing Chen, Gang Li, Hrvoje Miletic, Frits Thorsen, Rolf Bjerkvig, Xingang Li, Jian Wang
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:EMBO Molecular Medicine
Subjects:
24OHC
cholesterol homeostasis
CYP46A1
efavirenz
glioblastoma
Online Access:https://doi.org/10.15252/emmm.201910924

Internet

https://doi.org/10.15252/emmm.201910924

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