Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

Summary: The vagus nerve conveys gastrointestinal cues to the brain to control eating behavior. In obesity, vagally mediated gut-brain signaling is disrupted. Here, we show that the cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide synthesized proportional to the food consumed i...

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Bibliographic Details
Main Authors: Shin J. Lee, Jean-Philippe Krieger, Macarena Vergara, Danielle Quinn, Molly McDougle, Alan de Araujo, Rebecca Darling, Benjamin Zollinger, Seth Anderson, Annabeth Pan, Emilie J. Simonnet, Angelica Pignalosa, Myrtha Arnold, Arashdeep Singh, Wolfgang Langhans, Helen E. Raybould, Guillaume de Lartigue
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720300693

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http://www.sciencedirect.com/science/article/pii/S2211124720300693

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