Attenuating Hypoxia-Induced Apoptosis and Autophagy of Mesenchymal Stem Cells: the Potential of Sitagliptin in Stem Cell-Based Therapy

Attenuating Hypoxia-Induced Apoptosis and Autophagy of Mesenchymal Stem Cells: the Potential of Sitagliptin in Stem Cell-Based Therapy

Background/Aims: Dipeptidyl peptidase-4 (DPP-4) inhibitors have pleiotropic effects on cardiovascular protection beyond the antidiabetic property. However, it remains unknown that the impact of one DPP-4 inhibitor sitagliptin on the survival of mesenchymal stem cells (MSCs) in hypoxia and serum depr...

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Bibliographic Details
Main Authors: Xi-Mei Wang, Yue-Jin Yang, Yong-Jian Wu, Qian Zhang, Hai-Yan Qian
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Sitagliptin
Mesenchymal stem cell
Hypoxia
Apoptosis
Autophagy
Online Access:http://www.karger.com/Article/FullText/438552

Internet

http://www.karger.com/Article/FullText/438552

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