Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle

Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle

Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (NoX2) dependent ROS generation (X-ROS). Our work in dystrophic skeletal muscle revealed that X-ROS is excessive in dystrophin-deficien...

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Bibliographic Details
Main Authors: Ponvijay eKombairaju, Jaclyn P Kerr, Joseph A Roche, Stephen J.P Pratt, Richard M Lovering, Thomas E Sussan, Jung-Hyun eKim, Guoli eShi, Shyam eBiswal, Christopher William Ward
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Physiology
Subjects:
dystrophy
Nrf2
ROS
Dysferlin
X-ROS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00057/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00057/full

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