Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

As a cellular bile acid sensor, farnesoid X receptor (FXR) and the membrane G-coupled receptor (GPBAR1) participate in maintaining bile acid, lipid, and glucose homeostasis. To date, several selective and dual agonists have been developed as promising pharmacological approach to metabolic disorders,...

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Bibliographic Details
Main Authors: Claudia Finamore, Giuliana Baronissi, Silvia Marchianò, Francesco Saverio Di Leva, Adriana Carino, Maria Chiara Monti, Vittorio Limongelli, Angela Zampella, Stefano Fiorucci, Valentina Sepe
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
FXR agonists
bile acid receptors
steroidal scaffolds
medicinal chemistry
Online Access:http://www.mdpi.com/1420-3049/24/6/1043

Internet

http://www.mdpi.com/1420-3049/24/6/1043

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