Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

<p>Abstract</p> <p>Background</p> <p>A hallmark of Alzheimer’s disease is the presence of senile plaques in human brain primarily containing the amyloid peptides Aβ<sub>42</sub> and Aβ<sub>40</sub>. Many drug discovery efforts have focused on dec...

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Bibliographic Details
Main Authors:	Rogers Kathryn, Felsenstein Kevin M, Hrdlicka Lori, Tu Zhiming, Albayya Faris, Lee Winnie, Hopp Sarah, Miller Mary-Jo, Spaulding Darcie, Yang Zhiyong, Hodgdon Hilliary, Nolan Scott, Wen Melody, Costa Don, Blain Jean-Francois, Freeman Emily, De Strooper Bart, Vulsteke Veerle, Scrocchi Louise, Zetterberg Henrik, Portelius Erik, Hutter-Paier Birgit, Havas Daniel, Ahlijanian Michael, Flood Dorothy, Leventhal Liza, Shapiro Gideon, Patzke Holger, Chesworth Richard, Koenig Gerhard
Format:	Article
Language:	English
Published:	BMC 2012-12-01
Series:	Molecular Neurodegeneration
Subjects:	γ-secretase Modulation NSAID Cognition Amyloid Alzheimer’s disease
Online Access:	http://www.molecularneurodegeneration.com/content/7/1/61

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http://www.molecularneurodegeneration.com/content/7/1/61