Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

<p>Abstract</p> <p>Background</p> <p>The deleterious effect of a mutation can be reverted by a second-site interacting residue. This is an epistatic compensatory process explaining why mutations that are deleterious in some species are tolerated in phylogenetically rela...

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Bibliographic Details
Main Authors: Moleirinho Ana, van Asch Barbara, Carneiro João, Azevedo Luísa, Pereira Filipe, Amorim António
Format: Article
Language:English
Published: BMC 2009-06-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/10/266