Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition

Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition

An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations a...

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Bibliographic Details
Main Authors: Wen-Chang Chen, Veerababurao Kavala, Yu-Hsuan Shih, Yu-Hsuan Wang, Chun-Wei Kuo, Tang-Hao Yang, Chia-Yu Huang, Hao-Hsiang Chiu, Ching-Fa Yao
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
bicyclic isoxazole/isoxazolines
cycloaddition
nitrile oxide
nitroalkane
Yamaguchi reagent
Online Access:http://www.mdpi.com/1420-3049/20/6/10910

Internet

http://www.mdpi.com/1420-3049/20/6/10910

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