Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition

An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations a...

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Main Authors:	Wen-Chang Chen, Veerababurao Kavala, Yu-Hsuan Shih, Yu-Hsuan Wang, Chun-Wei Kuo, Tang-Hao Yang, Chia-Yu Huang, Hao-Hsiang Chiu, Ching-Fa Yao
Format:	Article
Language:	English
Published:	MDPI AG 2015-06-01
Series:	Molecules
Subjects:	bicyclic isoxazole/isoxazolines cycloaddition nitrile oxide nitroalkane Yamaguchi reagent
Online Access:	http://www.mdpi.com/1420-3049/20/6/10910

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spelling	doaj-904256cfdf31455ea97c97731ce6ad482020-11-24T20:57:08ZengMDPI AGMolecules1420-30492015-06-01206109101092710.3390/molecules200610910molecules200610910Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide CycloadditionWen-Chang Chen0Veerababurao Kavala1Yu-Hsuan Shih2Yu-Hsuan Wang3Chun-Wei Kuo4Tang-Hao Yang5Chia-Yu Huang6Hao-Hsiang Chiu7Ching-Fa Yao8Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanDepartment of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, TaiwanAn efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.http://www.mdpi.com/1420-3049/20/6/10910bicyclic isoxazole/isoxazolinescycloadditionnitrile oxidenitroalkaneYamaguchi reagent
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wen-Chang Chen Veerababurao Kavala Yu-Hsuan Shih Yu-Hsuan Wang Chun-Wei Kuo Tang-Hao Yang Chia-Yu Huang Hao-Hsiang Chiu Ching-Fa Yao
spellingShingle	Wen-Chang Chen Veerababurao Kavala Yu-Hsuan Shih Yu-Hsuan Wang Chun-Wei Kuo Tang-Hao Yang Chia-Yu Huang Hao-Hsiang Chiu Ching-Fa Yao Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition Molecules bicyclic isoxazole/isoxazolines cycloaddition nitrile oxide nitroalkane Yamaguchi reagent
author_facet	Wen-Chang Chen Veerababurao Kavala Yu-Hsuan Shih Yu-Hsuan Wang Chun-Wei Kuo Tang-Hao Yang Chia-Yu Huang Hao-Hsiang Chiu Ching-Fa Yao
author_sort	Wen-Chang Chen
title	Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_short	Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_full	Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_fullStr	Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_full_unstemmed	Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
title_sort	synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2015-06-01
description	An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.
topic	bicyclic isoxazole/isoxazolines cycloaddition nitrile oxide nitroalkane Yamaguchi reagent
url	http://www.mdpi.com/1420-3049/20/6/10910
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Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition

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