Modulation of human valve interstitial cell phenotype and function using a fibroblast growth factor 2 formulation.

Valve interstitial cells (VICs) are fibroblastic in nature however in culture it is widely accepted that they differentiate into a myofibroblastic phenotype. This study assessed a fibroblast culture media formulation for its ability to maintain the phenotype and function of VICs as in the intact hea...

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Bibliographic Details
Main Authors: Najma Latif, Alfred Quillon, Padmini Sarathchandra, Ann McCormack, Alec Lozanoski, Magdi H Yacoub, Adrian H Chester
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4456368?pdf=render