Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation

TAR DNA-binding protein 43 (TDP43) plays a significant role in familiar and sporadic amyotrophic lateral sclerosis (ALS). The diverse postulated mechanisms by which TDP43 mutations cause the disease are not fully understood. Human wildtype and TDP43 S393L and G294V mutant spinal motor neuron culture...

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Bibliographic Details
Main Authors: N. Kreiter, A. Pal, X. Lojewski, P. Corcia, M. Naujock, P. Reinhardt, J. Sterneckert, S. Petri, F. Wegner, A. Storch, A. Hermann
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
TAR DNA binding protein 43
TARDBP
Neurodegeneration
Mitochondria
Lysosomes
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611830086X

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http://www.sciencedirect.com/science/article/pii/S096999611830086X

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