Mutation screening in the genes PAX-8, NKX2-5, TSH-R, HES-1 in cohort of 63 Brazilian children with thyroid dysgenesis

Mutation screening in the genes PAX-8, NKX2-5, TSH-R, HES-1 in cohort of 63 Brazilian children with thyroid dysgenesis

ABSTRACT Objective: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. Subjects and methods: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid...

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Bibliographic Details
Main Authors: Taíse Lima de Oliveira Cerqueira, Yanne Rocha Ramos, Giorgia Bruna Strappa, Mariana Souza de Jesus, Jailciele Gonzaga Santos, Camila Sousa, Gildásio Carvalho, Vladimir Fernandes, Ney Boa-Sorte, Tatiana Amorim, Thiago Magalhães Silva, Ana Marice Teixeira Ladeia, Angelina Xavier Acosta, Helton Estrela Ramos
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism
Series:Archives of Endocrinology and Metabolism
Subjects:
Thyroid dysgenesis
congenital hypothyroidism
transcription factors
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000400466&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000400466&lng=en&tlng=en

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