Distinct Roles for CXCR6(+) and CXCR6(-) CD4(+) T Cells in the Pathogenesis of Chronic Colitis.

Distinct Roles for CXCR6(+) and CXCR6(-) CD4(+) T Cells in the Pathogenesis of Chronic Colitis.

CD4(+) T cells play a central role in the development of inflammatory bowel disease (IBD) via high-level production of effector cytokines such as IFN-γ and TNF-α. To better characterize the colitogenic CD4(+) T cells, we examined their expression of CXCR6, a chemokine receptor that is expressed by T...

Full description

Bibliographic Details
Main Authors: Yasushi Mandai, Daisuke Takahashi, Koji Hase, Yuuki Obata, Yukihiro Furusawa, Masashi Ebisawa, Tomoo Nakagawa, Toru Sato, Tatsuro Katsuno, Yasushi Saito, Takeshi Shimaoka, Osamu Yokosuka, Kotaro Yokote, Hiroshi Ohno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3686755?pdf=render

Internet

http://europepmc.org/articles/PMC3686755?pdf=render

Similar Items