Panobinostat Effectively Increases Histone Acetylation and Alters Chromatin Accessibility Landscape in Canine Embryonic Fibroblasts but Does Not Enhance Cellular Reprogramming

Panobinostat Effectively Increases Histone Acetylation and Alters Chromatin Accessibility Landscape in Canine Embryonic Fibroblasts but Does Not Enhance Cellular Reprogramming

Robust and reproducible protocols to efficiently reprogram adult canine cells to induced pluripotent stem cells are still elusive. Somatic cell reprogramming requires global chromatin remodeling that is finely orchestrated spatially and temporally. Histone acetylation and deacetylation are key regul...

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Bibliographic Details
Main Authors: Maryam Moshref, Maria Questa, Veronica Lopez-Cervantes, Thomas K. Sears, Rachel L. Greathouse, Charles K. Crawford, Amir Kol
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Veterinary Science
Subjects:
canine iPSC
embryonic fibroblasts
cellular reprogramming
HDAC inhibitors
ATAC sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2021.716570/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2021.716570/full

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