GTPase activity plays a key role in the pathobiology of LRRK2.

GTPase activity plays a key role in the pathobiology of LRRK2.

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, including functional Roc GTPase and protein kin...

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Bibliographic Details
Main Authors: Yulan Xiong, Candice E Coombes, Austin Kilaru, Xiaojie Li, Aaron D Gitler, William J Bowers, Valina L Dawson, Ted M Dawson, Darren J Moore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2851569?pdf=render

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http://europepmc.org/articles/PMC2851569?pdf=render

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