MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans

The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and neurodegeneration in vivo. Loss of MEC-6, a putative DEG/ENaC-specific chaperone, and of the s...

Full description

Bibliographic Details
Main Authors: Yushu Chen, Shashank Bharill, Robert O’Hagan, Ehud Y. Isacoff, Martin Chalfie
Format: Article
Language:English
Published: Oxford University Press 2016-04-01
Series:G3: Genes, Genomes, Genetics
Subjects:
DEG/ENaC channels
Caenorhabditis elegans
physiological suppressors
touch sensitivity
neurodegeneration
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.115.023507

Internet

http://g3journal.org/lookup/doi/10.1534/g3.115.023507

Similar Items