The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.

Aging is associated with functional decline in the immune system and increases the risk of chronic diseases owing to smoldering inflammation. In the present study, we demonstrated an age-related increase in the accumulation of Programmed Death-1 (PD-1)+ memory-phenotype T cells that are considered &...

Full description

Bibliographic Details
Main Authors: Xiaoxiang Yan, Natsumi Imano, Kayoko Tamaki, Motoaki Sano, Ken Shinmura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0252547