Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1

Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1

Indian gooseberry, also known as amla, a widely consumed fruit in South Asia, was evaluated for its anti-proliferative and pro-apoptotic mechanisms on human colon cancer stem cells (HCCSC). Amla extracts suppressed proliferation and induced apoptosis independent of p53, a tumour suppressor gene, in...

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Bibliographic Details
Main Authors: Ramakrishna Vadde, Sridhar Radhakrishnan, Hewage Eranda Karunathilake Kurundu, Lavanya Reddivari, Jairam K.P. Vanamala
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Functional Foods
Subjects:
Colon cancer
Cancer stem cells
Amla (Emblica officinalis Gaertn.) seed and pulp
Proliferation
Apoptosis
Wnt/β-catenin signalling
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616301505

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http://www.sciencedirect.com/science/article/pii/S1756464616301505

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