RUNX1 mutation and elevated FLT3 gene expression cooperates to induce inferior prognosis in cytogenetically normal acute myeloid leukemia patients

RUNX1 mutation and elevated FLT3 gene expression cooperates to induce inferior prognosis in cytogenetically normal acute myeloid leukemia patients

Background: Acute myeloid leukemia (AML) is a bone marrow malignancy having multiple molecular pathways driving its progress. In recent years, the main causes of AML considered all over the world are genetic variations in cancerous cells. The RUNX1 and FLT3 genes are necessary for the normal hematop...

Full description

Bibliographic Details
Main Authors: Atia Rehman, Afia Muhammad Akram, Asma Chaudhary, Nadeem Sheikh, Zawar Hussain, Walaa F. Alsanie, Rahat Abdul Rehman, Naila Hameed, Tayyaba Saleem, Amjad Zafar, Muhammad Absar, Zafar Iqbal, Alaa Alhazmi, Hosam Ali Baeshen, Zuhair M Mohammedsaleh, Samina Qamer, Samy Sayed, Ahmed Gaber
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Saudi Journal of Biological Sciences
Subjects:
RUNX1
FLT3
Mutations
Prognosis
Acute myeloid leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X21005854

Internet

http://www.sciencedirect.com/science/article/pii/S1319562X21005854

Similar Items