Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity

Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity

Entada africana is used in non-conventional medicine for the management of liver ailments. A fraction, designated EaF10 (methylene chloride/methanol 90:10, v/v) with promising hepatoprotective activity has been isolated. Since the mechanisms underlying EaF10 hepatoprotective action remain unknown, t...

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Bibliographic Details
Main Authors: Arnaud Fondjo Kouam, Brice Ayissi Owona, Rodrigue Fifen, Frédéric Nico Njayou, Paul Fewou Moundipa
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Heliyon
Subjects:
Entada africana
Fraction EaF10
Carbon tetrachloride
Anti-hepatotoxic
CYP2E1
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020314468

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http://www.sciencedirect.com/science/article/pii/S2405844020314468

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