Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling

Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling

Abstract Background Profound chemoresistance remains an intractable obstacle in pancreatic cancer treatment. Pancreatic cancer stem cells (CSCs) and the ubiquitous hypoxic niche have been proposed to account for drug resistance. However, the mechanism involved requires further exploration. This stud...

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Bibliographic Details
Main Authors: Zhengle Zhang, Han Han, Yuping Rong, Kongfan Zhu, Zhongchao Zhu, Zhigang Tang, Chenglong Xiong, Jing Tao
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gemcitabine
Hypoxia
Cancer stem cell
AKT
Notch1
Online Access:http://link.springer.com/article/10.1186/s13046-018-0972-3

Internet

http://link.springer.com/article/10.1186/s13046-018-0972-3

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