Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.

Bibliographic Details
Main Authors: Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25102-8

Internet

https://doi.org/10.1038/s41467-021-25102-8

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