Excess DHA Induces Cell Cycle Arrest by Activating the P53/Cycling Pathway in Blunt Snout Bream (Megalobrama amblycephala)

Excess DHA Induces Cell Cycle Arrest by Activating the P53/Cycling Pathway in Blunt Snout Bream (Megalobrama amblycephala)

A previous study showed that diets with high levels of docosahexaenoic acid (DHA) cause growth retardation in Megalobrama amblycephala. In order to explore the mechanisms involved, a feeding trial and a primary hepatocyte culture experiment were designed. In vivo, fish (average weight 26.40 ± 0.11 g...

Full description

Bibliographic Details
Main Authors: Cong-cong Wang, Wen-bin Liu, Xiu-fei Cao, Yang-yang Huang, Xi Wang, Kang Xiao, Xiang-fei Li, Ding-dong Zhang, Guang-zhen Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Marine Science
Subjects:
docosahexaenoic acid
cell cycle arrest
apoptosis
P53
cycling family
Megalobrama amblycephala
Online Access:https://www.frontiersin.org/article/10.3389/fmars.2020.00286/full

Internet

https://www.frontiersin.org/article/10.3389/fmars.2020.00286/full

Similar Items