Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts

Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts

Aims/hypothesis: Changes in cardiac metabolism and ion homeostasis precede and drive cardiac remodeling and heart failure development. We previously demonstrated that sodium/glucose cotransporter 2 inhibitors (SGLT2i's) have direct cardiac effects on ion homeostasis, possibly through inhibition...

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Bibliographic Details
Main Authors: Hong Zhang, Laween Uthman, Diane Bakker, Sahinda Sari, Sha Chen, Markus W. Hollmann, Ruben Coronel, Nina C. Weber, Sander M. Houten, Michel van Weeghel, Coert J. Zuurbier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
SGLT2
glycolysis
glucose oxidation
fatty acid oxidation
NHE
diastolic function
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.592233/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2020.592233/full

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