Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer

Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer

Abstract Background Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1 levels with cachexia and jaundice, two common PDAC-associated conditio...

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Bibliographic Details
Main Authors: Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L. Prokopchuk, Elaine C. Schubert, Helmut Friess, Marc E. Martignoni, Achim Krüger
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
TIMP-1
Cachexia biomarker
Pancreas
Jaundice
Online Access:http://link.springer.com/article/10.1186/s12885-018-4055-9

Internet

http://link.springer.com/article/10.1186/s12885-018-4055-9

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