Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

Mammalian sirtuin 6 (Sirt6) is a conserved NAD+-dependent deacylase and mono-ADP ribosylase that is known to be involved in DNA damage repair, metabolic homeostasis, inflammation, tumorigenesis, and aging. Loss of Sirt6 in mice results in accelerated aging and premature death within a month. Here, w...

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Bibliographic Details
Main Authors: Shrestha Ghosh, Sheung Kin Wong, Zhixin Jiang, Baohua Liu, Yi Wang, Quan Hao, Vera Gorbunova, Xinguang Liu, Zhongjun Zhou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
SIRT6
Trp53
lifespan extention
acetylation
premature aging
mice
Online Access:https://elifesciences.org/articles/32127

Internet

https://elifesciences.org/articles/32127

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