Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

Left ventricular (LV) hypertrophy (LVH) is a heritable trait that is common in type 2 diabetes and is associated with the development of heart failure. The transcriptional factor Kruppel like factor 15 (KLF15) is expressed in the heart and acts as a repressor of cardiac hypertrophy in experimental m...

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Bibliographic Details
Main Authors: Sheila K. Patel, Bryan Wai, Chim C. Lang, Daniel Levin, Colin N.A. Palmer, Helen M. Parry, Elena Velkoska, Stephen B. Harrap, Piyush M. Srivastava, Louise M. Burrell
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
Kruppel like factor 15
Left ventricular hypertrophy
Type 2 diabetes
Genetic association study
Echocardiogram
Heart failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301329

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http://www.sciencedirect.com/science/article/pii/S2352396417301329

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