Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1

Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1

Pathogenic intestinal bacteria lead to significant disease in humans. Here we investigated the role of the multifunctional protein, Apurinic/apyrimidinic endonuclease 1 (APE1), in regulating the internalization of bacteria into the intestinal epithelium. Intestinal tumor-cell lines and primary human...

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Bibliographic Details
Main Authors: Gerco den Hartog, Lindsay D. Butcher, Amber L. Ablack, Laura A. Pace, Jailal N. G. Ablack, Richard Xiong, Soumita Das, Thaddeus S. Stappenbeck, Lars Eckmann, Peter B. Ernst, Sheila E. Crowe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
intestinal epithelial barrier
invasion
internalization
Rac1
Salmonella Typhimurium
AIEC LF82 strain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.553994/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.553994/full

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