A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis.

A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis.

The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) regulates nuclear-factor-kappa-B (NF-κB) activation downstream of surface receptors with immunoreceptor tyrosine-based activation motifs (ITAMs), such as the B-cell or T-cell receptor and has thus emerged as a...

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Main Authors: Celine Dumont, Ulf Sivars, Theresa Andreasson, Lina Odqvist, Johan Mattsson, Amy DeMicco, Katerina Pardali, Gustav Johansson, Linda Yrlid, Rhona J Cox, Frank Seeliger, Marie Larsson, Ulf Gehrmann, Andrew M Davis, Outi Vaarala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222548

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https://doi.org/10.1371/journal.pone.0222548

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