Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model.

Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model.

Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. Cryptosporidium parvum infection of dairy calves, however,...

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Bibliographic Details
Main Authors: Erin Stebbins, Rajiv S Jumani, Connor Klopfer, John Barlow, Peter Miller, Mary A Campbell, Marvin J Meyers, David W Griggs, Christopher D Huston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5774826?pdf=render

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http://europepmc.org/articles/PMC5774826?pdf=render

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