Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy

Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy

Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of the HSP20–phosphodiesterase 4D (PDE4D) complex results in att...

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Bibliographic Details
Main Authors: Tamara P. Martin, Maria P. Hortigon-Vinagre, Jane E. Findlay, Christina Elliott, Susan Currie, George S. Baillie
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
cAMP
PDE4D
HSP20
Cardiac remodeling
Cardiac hypertrophy
Peptide disruption
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314001004

Internet

http://www.sciencedirect.com/science/article/pii/S2211546314001004

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