Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy
Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of the HSP20–phosphodiesterase 4D (PDE4D) complex results in att...
Main Authors: | Tamara P. Martin, Maria P. Hortigon-Vinagre, Jane E. Findlay, Christina Elliott, Susan Currie, George S. Baillie |
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Format: | Article |
Language: | English |
Published: |
Wiley
2014-01-01
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Series: | FEBS Open Bio |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211546314001004 |
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