PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer

PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer

Abstract Cancer-associated fibroblasts (CAFs) play significant roles in drug resistance through different ways. Antitumor therapies, including molecular targeted interventions, not only effect tumor cells but also modulate the phenotype and characteristics of CAFs, which can in turn blunt the therap...

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Bibliographic Details
Main Authors: Xiaoting Li, Tian Fang, Sen Xu, Ping Jin, Dongchen Zhou, Zhengzheng Wang, Huayi Li, Zongyuan Yang, Gang Chen, Xu Zheng, Yu Xia, Xiao Wei, Zeyu Zhang, Xin Yang, Ya Wang, Qinglei Gao
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-021-00189-w

Internet

https://doi.org/10.1038/s41698-021-00189-w

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