The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading

The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading

Abstract Background The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. Estrogen receptor beta (ERβ) is endowed wit...

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Bibliographic Details
Main Authors: Roberta Tarallo, Giorgio Giurato, Giuseppina Bruno, Maria Ravo, Francesca Rizzo, Annamaria Salvati, Luca Ricciardi, Giovanna Marchese, Angela Cordella, Teresa Rocco, Valerio Gigantino, Biancamaria Pierri, Giovanni Cimmino, Luciano Milanesi, Concetta Ambrosino, Tuula A. Nyman, Giovanni Nassa, Alessandro Weisz
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Genome Biology
Subjects:
Argonaute 2
Estrogen receptor beta
Breast cancer
Interaction proteomics
Transcriptional regulation
RNA splicing
Online Access:http://link.springer.com/article/10.1186/s13059-017-1321-0

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http://link.springer.com/article/10.1186/s13059-017-1321-0

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