A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL).The stability testing of four novel oral lipid AmB formulations composed of mono- and di-gl...

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Bibliographic Details
Main Authors: Ellen K Wasan, Pavel Gershkovich, Jinying Zhao, Xiaohua Zhu, Karl Werbovetz, Richard R Tidwell, John G Clement, Sheila J Thornton, Kishor M Wasan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC2998436?pdf=render

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http://europepmc.org/articles/PMC2998436?pdf=render

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