Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.

Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection.

Staphylococcus aureus frequently invades the human bloodstream, leading to life threatening bacteremia and often secondary foci of infection. Failure of antibiotic therapy to eradicate infection is frequently described; in some cases associated with altered S. aureus antimicrobial resistance or the...

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Bibliographic Details
Main Authors: Wei Gao, Kyra Chua, John K Davies, Hayley J Newton, Torsten Seemann, Paul F Harrison, Natasha E Holmes, Hyun-Woo Rhee, Jong-In Hong, Elizabeth L Hartland, Timothy P Stinear, Benjamin P Howden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20548948/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20548948/pdf/?tool=EBI

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