Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes
The relationship between soy intake (SI) and breast cancer (BC) has been widely investigated with limited information on the significance of hormone receptor status of BC on the association. This study assessed the relationship between SI and BC risk in the context of oestrogen receptor (ER) status...
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doaj-90b781173e4b4f39892d91b61c771dd82020-11-25T03:55:42ZengElsevierHeliyon2405-84402020-07-0167e04228Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypesAkinkunmi Paul Okekunle0Jian Gao1Xiaoyan Wu2Rennan Feng3Changhao Sun4Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, People's Republic of China; Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, 200284, Nigeria; The Postgraduate College, University of Ibadan, Ibadan 200284, Nigeria; Corresponding author.Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, People's Republic of ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, People's Republic of ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, People's Republic of China; Corresponding author.Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, People's Republic of China; Corresponding author.The relationship between soy intake (SI) and breast cancer (BC) has been widely investigated with limited information on the significance of hormone receptor status of BC on the association. This study assessed the relationship between SI and BC risk in the context of oestrogen receptor (ER) status of BC. We meta-analyzed data from published studies on SI and BC after a methodical search of EMBASE, PubMed and Cochrane Library through December 2019. Summary estimates with 95% confidence intervals (CI) were presented using a random-effects model. Eighteen (5 cohorts and 13 case-control) studies, were included in this meta-analysis and SI was inversely associated with BC risk [OR (95%) for highest vs. lowest soy food intake = 0.88 (0.84–0.92), P < 0.001, I2 = 76.1%, Egger's p-value = 0.425] among all women. The inverse relationship was stronger among premenopausal women [OR (95%) = 0.79 (0.71–0.87), P < 0.001, I2 = 77.3%, Egger's p-value = 0.644]. In addition, SI was inversely associated with BC risk among ER-negative (–) BC women [OR (95%) = 0.71 (0.57–0.90), P = 0.013, I2 = 72.0%, Egger's p-value = 0.355] and among ER-positive (+) BC women [OR (95%) = 0.87 (0.79–0.96), P = 0.008 I2 = 74.6%, Egger's p-value = 0.061]. SI appears inversely associated with BC risk, with a stronger inverse association among pre-menopausal and ER-negative BC women.http://www.sciencedirect.com/science/article/pii/S2405844020310720Food scienceEpidemiologyCancer researchNutritionSoyBreast cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akinkunmi Paul Okekunle Jian Gao Xiaoyan Wu Rennan Feng Changhao Sun |
spellingShingle |
Akinkunmi Paul Okekunle Jian Gao Xiaoyan Wu Rennan Feng Changhao Sun Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes Heliyon Food science Epidemiology Cancer research Nutrition Soy Breast cancer |
author_facet |
Akinkunmi Paul Okekunle Jian Gao Xiaoyan Wu Rennan Feng Changhao Sun |
author_sort |
Akinkunmi Paul Okekunle |
title |
Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes |
title_short |
Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes |
title_full |
Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes |
title_fullStr |
Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes |
title_full_unstemmed |
Higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes |
title_sort |
higher dietary soy intake appears inversely related to breast cancer risk independent of estrogen receptor breast cancer phenotypes |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2020-07-01 |
description |
The relationship between soy intake (SI) and breast cancer (BC) has been widely investigated with limited information on the significance of hormone receptor status of BC on the association. This study assessed the relationship between SI and BC risk in the context of oestrogen receptor (ER) status of BC. We meta-analyzed data from published studies on SI and BC after a methodical search of EMBASE, PubMed and Cochrane Library through December 2019. Summary estimates with 95% confidence intervals (CI) were presented using a random-effects model. Eighteen (5 cohorts and 13 case-control) studies, were included in this meta-analysis and SI was inversely associated with BC risk [OR (95%) for highest vs. lowest soy food intake = 0.88 (0.84–0.92), P < 0.001, I2 = 76.1%, Egger's p-value = 0.425] among all women. The inverse relationship was stronger among premenopausal women [OR (95%) = 0.79 (0.71–0.87), P < 0.001, I2 = 77.3%, Egger's p-value = 0.644]. In addition, SI was inversely associated with BC risk among ER-negative (–) BC women [OR (95%) = 0.71 (0.57–0.90), P = 0.013, I2 = 72.0%, Egger's p-value = 0.355] and among ER-positive (+) BC women [OR (95%) = 0.87 (0.79–0.96), P = 0.008 I2 = 74.6%, Egger's p-value = 0.061]. SI appears inversely associated with BC risk, with a stronger inverse association among pre-menopausal and ER-negative BC women. |
topic |
Food science Epidemiology Cancer research Nutrition Soy Breast cancer |
url |
http://www.sciencedirect.com/science/article/pii/S2405844020310720 |
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