Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways.

Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways.

Since their isolation until implantation, pancreatic islets suffer a major stress leading to the activation of inflammatory reactions. The maintenance of controlled inflammation is essential to preserve survival and function of the graft. Identification and targeting of pathway(s) implicated in post...

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Bibliographic Details
Main Authors: Kevin Vivot, Allan Langlois, William Bietiger, Stéphanie Dal, Elodie Seyfritz, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Jean-Pierre Gies, Séverine Sigrist
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4208733?pdf=render

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http://europepmc.org/articles/PMC4208733?pdf=render

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