Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus

Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus

Workplace exposure to respirable crystalline silica dust (cSiO2) has been etiologically linked to the development of lupus and other human autoimmune diseases. Lupus triggering can be recapitulated in female NZBWF1 mice by four weekly intranasal instillations with 1 mg cSiO2. This elicits inflammato...

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Bibliographic Details
Main Authors: James J. Pestka, Peyman Akbari, Kathryn A. Wierenga, Melissa A. Bates, Kristen. N. Gilley, James G. Wagner, Ryan P. Lewandowski, Lichchavi D. Rajasinghe, Preeti S. Chauhan, Adam L. Lock, Quan-Zhen Li, Jack R. Harkema
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
NZBWF1
ω-3 polyunsaturated fatty acid
silica
docosahexaenoic acid
ectopic lymphoid structure
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.653464/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.653464/full

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